Summary:

This internationally renowned reference work is a fully updated and expanded second edition of the most comprehensive title available on pleural diseases.

Building on the many strengths of the highly respected first edition, the book features a detailed yet lucid basic science section to support understanding of the physiological and pathophysiological mechanisms that underlie diseases of the pleura. This is followed by a wide-ranging series of clinical chapters, discussing both familiar and less common aspects of pleural diseases.

Chapters in the clinical section are written in an accessible and uniform style, making extensive use of illustrative material and covering definition, incidence and epidemiology, etiology and pathogenesis, clinical presentation, investigations, treatments, possible complications and directions for future development. State-of-the-art scientific knowledge is presented at an appropriate level for the practicing clinician, and published management guidelines are included where relevant. Each chapter concludes with a summary of its 'key points', highlighting practical messages regarding patient management for the reader.

Textbook of Pleural Diseases is an indispensable reference for pulmonary physicians and trainees worldwide.

• Comprehensively covers both the basic science and the clinical aspects of pleural disease with meticulous referencing
• Written by an international authorship, selected by highly respected editors from the UK and USA
• Each chapter highlights key patient management issues in concise and memorable bulleted lists
• Histological and other selected images are presented in full color to aid understanding

Table of Contents:

Pleural disease: historic perspective
 
PART ONE: Basic Science
Anatomy of the pleura
Mesothelial cells
Normal physiological fluid and cellular contents
Physiology: fluid and solute exchange in normal physiological states
Physiology: changes with pleural effusion and pneumothorax
Pleural inflammation and infection
Immunology
Pleural fibrosis
Pleural reaction to mineral dusts
Genetic alterations in mesothelioma pathogenesis
Proteomics in pleural disease
Pleural pharmacokinetics
Experimental models: pleural disease other than mesothelioma
Experimental models: mesothelioma
 
PART TWO: Clinical Science
Approach to patients with pleural diseases
Pleural fluid analysis
Pleural manometry
Radiology: diagnostic
Radiology: interventional
Radiology: pleural ultrasound
Pathology: histology
Pathology: cytology
EFFUSIONS
Effusions from cardiac diseases
Effusions from malignancy
Effusions from infections: parapneumonic effusions and empyema
Effusions from infections: tuberculosis
Effusions from infections: atypical infections
Effusions from lymphatic disruptions
Effusions from vascular causes
Effusions in immunocompromised hosts
Effusions from connective tissue diseases
Effusions caused by drugs
Effusions after surgery
Hepatic hydrothorax
Effusions caused by gastrointestinal disease
Effusions of obstetric or gynecological origin
Benign fibrous tumor of the pleura
Undiagnosed pleural effusions
ASBESTOS-RELATED DISEASES
Asbestos-related pleural diseases
Malignant mesothelioma
PNEUMOTHORAX
Spontaneous pneumothorax
Non-spontaneous pneumothorax
PEDIATRIC CONSIDERATIONS
Pediatric pleural diseases
INTERVENTION PROCEDURES
Drainage techniques
Pleurodesis
Medical thoracoscopy
Surgery for pleural diseases
Gene therapy in pleural diseases
CONCLUSION
Future directions

About the Author(s):
Richard W Light MD FCCP Professor of Medicine, Vanderbilt University, Nashville, TN, USA

YC Gary Lee MBChB PhD FRACP FCCP Consultant Chest Physician and Senior Lecturer, Oxford Centre for Respiratory Medicine and University of Oxford, Oxford, UK; Research Team Leader, Centre for Respiratory Research, University College London, London, UK; and Associate Professor (Honorary), University of Western Australia, Perth, Australia

Contributors:
76 contributors from around the world

Readership:
Core Readership: Pulmonologists; researchers (both clinical and non-clinical) with an interest in the pleura; Supplementary Readership: Trainees in respiratory medicine